Research Examples
The research projects undertaken by CMMB IGERT Trainees and participating faculty will have potential impact and application in areas such as tissue and regenerative medicine and engineering, cellular and molecular medicine, mechanobiology, neuroscience, biosensing and actuation, cellular factories, and synthetic biology.
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Micro and Nanotechnology for Cell Mechanics Studies Silicon probe to measure cell mechanical properties (left), stereo-lithography to build a model of arterial branching structures (middle), and PEG structure (right). |
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Computations at Molecular Scale Nanosecond MD simulations of tetrameric GlpF in a hydrated patch of POPE lipid bilayer characterized the complete pathway of substrate conduction in the channel (Jansen 2001). |
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Growth, Development and Regeneration – Sub-cellular to Intercellular Scales Analysis of spine formation in hippocampal neurons for use in substrate-engineered micro environments. 3-D reconstruction of an
immature rat hippocampal neuron @ 11 days in vitro (DIV) reveals collateral Sequential image stacks enable 3-D cell reconstruction for quantitative analyses of filopodial size and branchpoints (10µm grid). |
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Single Molecule Imaging CCD image of a single Cy3 molecule. The width is ~250 nm, but the center can be located to within w/(S/N) where S/N = signal to noise. The S/N is ~√N, where
N = total number of photons;
N = 104 making the centers uncertainty ± 1.3 nm |